Zhong Xi Yi Jie He Xue Bao. 2011 Jun;9(6):688-92.                                                 free full text   

Li ZG.

Source

College of Foreign Languages, Shanghai Normal University, Shanghai 200234, China. این نشانی پست الکترونیک دربرابر spambot ها و هرزنامه ها محافظت می شود. برای مشاهده آن شما نیازمند فعال بودن جاواسکریپت هستید

Evid Based Complement Alternat Med. 2011;2011:513842. Epub 2011 Feb 17.          free full text  

Watanabe K, Matsuura K, Gao P, Hottenbacher L, Tokunaga H, Nishimura K, Imazu Y, Reissenweber H, Witt CM.

Source

Center for Kampo Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Zhong Xi Yi Jie He Xue Bao. 2011 Jun;9(6):626-31.                                            free full text  

Ali MK, Ashraf A, Biswas NN, Karmakar UK, Afroz S.

Source

Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh. این نشانی پست الکترونیک دربرابر spambot ها و هرزنامه ها محافظت می شود. برای مشاهده آن شما نیازمند فعال بودن جاواسکریپت هستید

Nutr Metab (Lond). 2011 Jun 29;8(1):46. [Epub ahead of print]                             free full text   

Shihabudeen MS, Priscilla H, Thirumurugan K.

ABSTRACT:

BACKGROUND:

Alpha-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursions. PPHG is a major risk factor for diabetic vascular complications leading to disabilities and mortality in diabetics. Cinnamomum zeylanicum, a spice, has been used in traditional medicine for treating diabetes. In this study we have evaluated the alpha-glucosidase inhibitory potential of cinnamon extract to control postprandial blood glucose level in maltose, sucrose loaded STZ induced diabetic rats.

METHODS:

The methanol extract of cinnamon bark was prepared by Soxhlet extraction. Phytochemical analysis was performed to find the major class of compounds present in the extract. The inhibitory effect of cinnamon extract on yeast alpha-glucosidase and rat-intestinal alpha-glucosidase was determined in vitro and the kinetics of enzyme inhibition was studied. Dialysis experiment was performed to find the nature of the inhibition. Normal male Albino wistar rats and STZ induced diabetic rats were treated with cinnamon extract to find the effect of cinnamon on postprandial hyperglycemia after carbohydrate loading.

RESULTS:

Phytochemical analysis of the methanol extract displayed the presence of tannins, flavonoids, glycosides, terpenoids, coumarins and anthraquinones. In vitro studies had indicated dose-dependent inhibitory activity of cinnamon extract against yeast alpha-glucosidase with the IC 50 value of 5.83 mug/ml and mammalian alpha-glucosidase with IC 50 value of 670 ug/ml. Enzyme kinetics data fit to LB plot pointed out competitive mode of inhibition and the membrane dialysis experiment revealed reversible nature of inhibition. In vivo animal experiments are indicative of ameliorated postprandial hyperglycemia as the oral intake of the cinnamon extract (300 mg/kg body wt.) significantly dampened the postprandial hyperglycemia by 78.2% and 52.0% in maltose and sucrose loaded STZ induced diabetic rats respectively, compared to the control. On the other hand, in rats that received glucose and cinnamon extract, postprandial hyperglycemia was not effectively suppressed, which indicates that the observed postprandial glycemic amelioration is majorly due to alpha-glucosidase inhibition.

CONCLUSIONS:

The current study demonstrates one of the mechanisms in which cinnamon bark extract effectively inhibits alpha-glucosidase leading to suppression of postprandial hyperglycemia in STZ induced diabetic rats loaded with maltose, sucrose. This bark extract shows competitive, reversible inhibition on alpha-glucosidase enzyme. Cinnamon extract could be used as a potential nutraceutical agent for treating postprandial hyperglycemia. In future, specific inhibitor has to be isolated from the crude extract, characterized and therapeutically exploited.

Indian J Pharmacol. 2011 May;43(3):336-9.                                                               free full text  

Sathish R, Sahu A, Natarajan K.

Source

Department of Pharmacology, Ultra College of Pharmacy, Madurai, Tamil Nadu, India.

Pharmacognosy Res. 2010 Nov;2(6):350-4.                                                           free full text   

Sharma RD, Veerpathran AR, Dakshinamoorthy G, Sahare KN, Goswami K, Reddy MV.

Source

Department of Biochemistry & JB Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, India.

Indian J Pharmacol. 2011 May;43(3):316-9.                                                           free full text   

Mandade RJ, Choudhury A, Harsulkar A, Wakade R.

Source

Department of Pharmacology, S. N. Institute of Pharmacy, Pusad, Yavatmal, Maharashtra, India.

Malar J. 2011 Jun 17;10:167.                                                                             free full text  

Zofou D, Kowa TK, Wabo HK, Ngemenya MN, Tane P, Titanji VP.

Source

Biotechnology Unit, University of Buea, P,O, Box 63 Buea, South West Region, Cameroon. این نشانی پست الکترونیک دربرابر spambot ها و هرزنامه ها محافظت می شود. برای مشاهده آن شما نیازمند فعال بودن جاواسکریپت هستید .

Yakugaku Zasshi. 2011;131(6):909-15.                                                                    free full text   

Nakamura S, Matsuda H, Yoshikawa M.

Source

Kyoto Pharmaceutical University.

Abstract

Many foods are known to have not only nutritive and taste values but also medicinal effects. In Chinese traditional medicine, the treatment using medicinal foods has been recommended highly. Recently, we examined the effects of the extract and constituents of several medicinal foods on experimental models of diabetes. In this paper, we focus on the bioactive constituents of four medicinal foods, namely the antidiabetic constituents from 1) the roots, stems and leaves of Salacia plants, 2) the male flowers of Borassus flabellifer, 3) the flower buds of Camellia sinensis, 4) the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).

Evid Based Complement Alternat Med. 2011;2011:568148. Epub 2011 Feb 20.          free full text  

Biswas R, Mandal SK, Dutta S, Bhattacharyya SS, Boujedaini N, Khuda-Bukhsh AR.

Source

Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, India.